EAST HOLLYWOOD, LOS ANGELES (KABC) — A remarkable story unfolds in the realm of biomedical engineering, showcasing the inspiring journey of a University of Southern California (USC) student who has created a transformative software application benefiting cancer treatment at Children’s Hospital Los Angeles.
Innovation in Cancer Treatment
Arjun Karnwal, a 20-year-old biomedical engineering major, is not just another college student; he is a visionary focused on improving healthcare solutions. While his peers are immersed in traditional studies, Karnwal is dedicated to innovating medical practices.
A Passion for Improvement
“I’m always sort of innovation-focused, and I always want to improve things even just by 1%,” said Karnwal, who studies at USC’s Alfred E. Mann Institute for Biomedical Engineering within the Viterbi School of Engineering. His commitment to making a difference began as early as high school, where he designed educational tools to assist his teachers.
Collaborating with Experts
Currently, Karnwal collaborates with radiation oncologists at Children’s Hospital Los Angeles (CHLA), asking critical questions about optimizing radiation delivery to maximize its effectiveness. This led him to develop an application called “ShotCaller,” which revolutionizes how radiation doses are planned.
The Impact of ShotCaller
Traditionally, planning radiation treatment would take doctors up to four hours. However, thanks to Karnwal’s innovative algorithm, that time has been reduced to under thirty minutes. According to Dr. Kenneth Wong, a radiation oncologist at CHLA, “With Arjun’s algorithm, we were able to come up with a plan in under half an hour.”
A New Approach to Complex Math
ShotCaller employs a cutting-edge technique called spatially-fractionated radiation, targeting large tumors that resist standard therapies. The application not only simplifies complex calculations but also enhances precision in determining the best locations for radiation. Karnwal likens this process to fitting tennis balls into a box, but with the added complexity of avoiding healthy tissue and vital organs.
Real-World Results
The results of using ShotCaller have been overwhelmingly positive. Wong noted that “the ShotCaller algorithm is actually better than our human attempts,” leading to increased treatment efficiency. This advancement has directly contributed to extending patients’ lives and alleviating their pain.
A Bright Future Ahead
As demand for Karnwal’s software grows, with several medical centers expressing interest, he reflects on the journey with gratitude. “I think it makes all the late nights and early mornings worth it, and I just feel grateful to have the chance to make something,” he remarked.
With his innovative spirit and determination, Arjun Karnwal exemplifies how young minds can pave the way for significant advancements in healthcare.
Copyright © 2025 KABC Television, LLC. All rights reserved.
Transforming Cancer Treatment: USC Student Develops Innovative App
Engineering a Solution for Cancer Care
In a groundbreaking effort to enhance cancer treatment, a University of Southern California biomedical engineering student has crafted a software application that significantly optimizes how doctors at Children’s Hospital Los Angeles administer radiation therapy. This innovation exemplifies the spirit of leveraging technology to improve healthcare outcomes.
A Mind Focused on Innovation
At just 20 years old, Arjun Karnwal is not your typical college student. Currently a junior at USC’s Alfred E. Mann Institute for Biomedical Engineering, he remains committed to finding innovative solutions that elevate patient care. “I always want to improve things, even just by 1%,” Karnwal stated, embodying the ethos of constant progress.
From Classrooms to Cancer Treatment
Even during his high school years at La Canada High, Karnwal demonstrated a passion for innovation by developing tools to assist teachers in their classrooms. This early fascination with technology eventually led him to collaborate with radiation oncologists at Children’s Hospital Los Angeles, where he sought meaningful projects to enhance medical practices.
The Advent of “ShotCaller”
Amidst the complexities of radiation therapy, Karnwal invented an application known as “ShotCaller.” This software dramatically reduces the planning time for radiation dose distribution, enabling doctors to focus more on patient care. “What used to take us three to four hours now can be accomplished in under 30 minutes,” noted Dr. Kenneth Wong, a radiation oncologist at CHLA.
Precision in Oncology
“ShotCaller” specializes in a cutting-edge technique called spatially-fractionated radiation, which targets hard-to-treat tumors. Karnwal ingeniously simplifies the complex mathematics involved in tumor radiation planning, leading to remarkably accurate treatments. His algorithm not only saves time but also increases the efficacy of the treatment.
Impact on Patient Care
The enhanced accuracy and efficiency offered by Karnwal’s app have resulted in reduced treatment delays and better outcomes for patients. Dr. Wong emphasizes that the app’s effectiveness surpasses traditional methods, stating, “The ShotCaller algorithm is actually better than our human attempts.” This advancement is vital in extending patient lives and minimizing their suffering.
A Bright Future Ahead
The response from the medical community has been overwhelmingly positive, with interest from various healthcare centers seeking to implement Karnwal’s innovative work. For him, the success of “ShotCaller” is the greatest reward. “It makes all the late nights and early mornings worth it,” he expressed, feeling gratitude for the opportunity to create something impactful in the realm of healthcare.

